3D Printed Porous Methacrylate/Silica Hybrid Scaffold for Bone Substitution

Inorganic–organic hybrid biomaterials made with star polymer poly(methyl methacrylate-co-3-(trimethoxysilyl)propyl methacrylate) and silica, which show promising mechanical properties, are 3D printed as bone substitutes for the first time, by direct ink writing of sol. Three different inorganic:organic ratios methacrylate)-star-SiO2 inks pore channels in range 100–200 µm. Mechanical properties scaffolds fall within trabecular bone, MC3T3 pre-osteoblast cells able to adhere vitro, regardless their compositions. Osteogenic angiogenic shown using a rat calvarial defect model. Hybrid 40:60 composition instigate new vascularized formation its polarize macrophages toward M2 phenotype. printing inorganic–organic hybrids sophisticated structure opens up possibilities produce novel graft materials.